The sun, the air, even sleeping — life takes its toll. Protandim, a patented formula, supplements what daily living takes out. 

Free Radicals, generated through the process of living life (eating, sleeping, breathing, exercising), are inevitable for everyone. But they cause Oxidative Stress which is BAD for our bodies. 

NOW there is a solution ...



When the body is young and healthy it is able to take care of the balance between cellular damage and repair and rejuvenation. One way the body takes care of repairing damage is to signal the production of antioxidant enzymes or survival genes through something known as the NRF2 pathway.


NRF2 is a powerful protein that is latent within each cell in the body, unable to move or operate until it is released by an NRF2 activator. Once released it migrates into the cell nucleus and bonds to the DNA at the location of the Antioxidant Response Element (ARE) or also called HARE (Human Antioxidant Response Element) which is the master regulator of the total antioxidant system that is available in ALL human cells.

This balancing act can become disrupted as one ages, or if the body is overcome by malfunction and disease resulting in further cellular damage. This damage is known as oxidative stress and is accompanied by free radical production. Oxidative stress and the associated free radical damage contribute to the progression of hundreds of diseases and aging symptoms.

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The first step to understanding how to fight oxidative stress is to understand just how many Free Radicals we have at any one time.

We have 37.2 Trillion cells - We potentially have millions of free radicals in each of those cells.

Let’s say we have 1 million free radicals in each cell. That equals a massive 3,720,000,000,000,000,000 (3.72 quintillion) Free Radicals in our bodies.

1 punnet of Blueberries has 6,700 anti-oxidants.

Direct antioxidants such as vitamin C, Vitamin E, berries and juices have typically been used to neutralise free radicals and to prevent the damage they cause. One molecule of antioxidants from these sources neutralises one free radical, i.e. they combat free radicals on a one to one ratio. However there comes a tipping point where the direct antioxidants are inadequate to take care of the damage.


The Right Choice

A better approach to fighting free radicals is to use the body’s own self defence mechanism. When NRF2 is activated in the nucleus, it turns on the production of antioxidant enzymes such as Catalase, Glutathione Peroxidase and Superoxide Dismutase (SOD). These antioxidant enzymes are powerful enough to neutralise millions of free radicals. This one to one million ratio proves to be a far more effective approach in combating aging and disease.

Nrf2 Activators

Since the Nrf2 protein remains dormant in a cell until it is activated by a Nrf2 activator. The challenge is to determine what activates Nrf2 to take advantage of the one to one million free radical neutralisation mentioned above?


Through the study of Nutrigenomics, (Nutri (nutrition) genomics (genes) ... it has been determined that a variety of foods are powerful activators of the Nrf2 pathway. We tested over 2500 varieties of herbs and finally cracked the code to activate the Nrf2 Pathway.

Dr. David Perlmutter M.D

Dr. David Perlmutter M.D

“While not necessarily rich in antioxidants, they directly and dramatically amplify our innate ability to produce vast antioxidant protection by signalling our DNA. In this way, specific molecules from Nrf2 activating foods can trigger the production of thousands of antioxidant molecules, providing far better protection against the brain-damaging effects of free radicals compared to standard antioxidant supplements.”

THE ANSWER – Protandim NRF2 – the worlds only peer reviewed proven natural NRF2 activator. Protandim is a daily dietary supplement that combats free radicals.




Our flagship product, Protandim NRF2 Synergizer, has 24 Published Peer-reviewed studies conducted in the laboratories of respected American Universities.

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Protandim Activates the Antioxidant Defense.

It’s made up of the 5 natural ingredients seen to the right. 

Protandim Ingredients