The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy.

Conclusion: Protandim Nrf2 reduces Oxidative Stress by 40% in 30 days.

Healthy Humans.

The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy.

“Protandim Nrf2 increased glutathione by 300% in the cells tested.

Also increases SOD by 30% and CAT by 54%.”

“Induction of antioxidant enzymes by Protandim® may serve as a practical and potent approach to cancer prevention.”

HEART ASSOCIATION OF USA

Chronic Pulmonary Artery- “RV (right ventricular) failure is associated with oxidative stress and reduced HO-1– dependent antioxidant protection. Restoration of Nrf2 and HO-1 signalling can prevent maladaptive RV remodelling and preserve RV function.”

“Nrf2 is a guardian of health span and the gatekeeper of species longevity... protecting against many age-related diseases including cancer and neurodegeneration.”

“The Dietary Supplement Protandim® Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy.”

OPN is implicated in the start of a variety of diseases.

Reduces hardening of veins
Intimal Hyperplasia study.

“Protandim® attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase- dependent pathway.”

Potential of Nrf2 Activation. Oxidative stress is linked to over 200 diseases.

“Protandim-regulated genes that are associated with Alzheimer disease, only five (SOD1, NQO1, HMOX1, GLRX, and TXN) appear to be in the antioxidant family. Protandim upregulated all five of them, but clearly there is more to the story than genes associated with oxidative stress. The focus on Nrf2 will not only broaden our view, it will provide practical solutions.”

The role of manganese superoxide dismutase in skin cancer.

“Protandim®, a combination of 5 well-studied medicinal plants, was given via dietary administration and significantly decreased tumour incidence and multiplicity by 33% and 57%, respectively. These studies suggest that alterations in antioxidant response may be a novel approach to chemoprevention.”

Study of Protandim vs Tecfidera BG-12

“Interestingly, Protandim®, a dietary supplement consisting of herbal ingredients, was the most potent inducer and therefore may be the most suited as a therapeutic strategy [for multiple sclerosis].”

Humans with alcohol use disorders.

Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge.

“Protects Human Coronary Artery.”

“These results support the use of phytochemicals in protection of cardiac myocytes against oxidant stress and suggest their potential use in treatment of cardiovascular disease. It remains to be determined in vivo if phytochemical Nrf2 activators hold promise for prevention and treatment of oxidative stress associated with chronic human diseases.”

“Nrf2 Activation: A potential strategy for the prevention of Acute Mountain Sickness.”

Role of Nrf2 in Cardiovascular Disease

“Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.”

“I believe this continuing study currently demonstrates the importance and utility of this supplement - for improving the health and quality of life of dogs as they age.” Dr Darlene Walley, Animal Health Consulting

Healthy overweight humans

Oxidative stress is decreased with short-term Protandim use when piperine is substituted for Ashwagandha (LB399).

The effect of Protandim supplementation on oxidative damage and athletic performance.

“No Increase or Decrease of Oxidative Stress noted in runners on Protandim.”

“Nrf2 is likely to be the most important health promoting approach in the foreseeable future. Nrf2 may become the most extraordinary therapeutic and preventative breakthrough in the history of medicine.”

Introduction to Special Issue on ‘Nrf2 Regulated Redox Signalling and Metabolism in Physiology and Medicine.’

NRF2 and Neurodegenerative Diseases

"I am very enthusiastic about this strategy for treating neurodegenerative diseases," said Finkbeiner, a senior investigator at Gladstone and senior author on the paper.

Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults.

“Protandim® is the only nutritional supplement tested that has been proven to increase the median survival in mice, thus delaying the aging process. It has the potential to extend lifespan and delay disease and dysfunction.”

After testing resveratrol, fish oil, green tea, curcumin.